Difficulty Levels Explained in Titan Quest 2
There are a few difficulty options to choose from in Titan Quest 2, with additional ways to alter the difficulty in-game; here's how it all works.

A lot of decisions made early in TitanQuest 2 are final. While some things, such as the way your character looks, don't have as much of an effect, other decisions, such as the difficulty and Masteries of your character, are set in stone.
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